Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer

来源与记录

• 文献来源：精科生物+合作伙伴共同发表
• 记录类型：SCI论文
• 影响因子 IF：56.1

文献信息

• 发表期刊：Cancer Cell
• 发表年份：2022
• 作者：Manli Wang, Xuelan Chen, Ping Tan, Yigao Wang, Xiangyu Pan, Tingting Lin, Yong Jiang, Bo Wang, Huan Xu, Yuying Wang, Yi Yang, Jian Wang, Lei Zhao, Jing Zhang, Ailing Zhong, Yiman Peng, Jiajia Du, Qi Zhang, Jianan Zheng, Jingyao Chen, Siqi Dai, Feifei Na, Zhenghao Lu, Jia Liu, Xi Zheng, Lu Yang, Peng Zhang, Ping Han, Qiyong Gong, Qian Zhong, Kanghua Xiao, Huiliang Yang, Hongxin Deng, Yinglan Zhao, Heng Xu, Jiangang Man, Maling Gou, Chengjian Zhao, Lunzhi Dai, Zhihui Xue, Lu Chen, Yuan Wang, Musheng Zeng, Canhua Huang, Qiang Wei, Yuquan Wei, Yu Liu, Chong Chen
• 标识信息：PMID: 36099882；DOI: 10.1016/j.ccell.2022.08.010
• 精科角色：内部人员参与发表（成都诺医德医学检验实验室有限公司）
• 证据状态：期刊：Cancer Cell；2025年JCR IF=56.1；中科院医学1区；JCR Q1

文献引用格式

Wang M, Chen X, Tan P, Wang Y, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q, Wei Y, Liu Y, Chen C. Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer. Cancer Cell. 2022 Sep 12;40(9):1044-1059.e8. doi: 10.1016/j.ccell.2022.08.010. Erratum in: Cancer Cell. 2025 May 12;43(5):985-987. doi: 10.1016/j.ccell.2025.04.010. PMID: 36099882.

精科解读

揭示膀胱癌化疗耐药的新机制——半鳞状分化，为克服化疗耐药提供分化治疗新思路。

备注

研究方向：膀胱癌研究